NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What does smoking induce that increases the risk of bleeding with warfarin and clopidogrel?

  1. CYP1A2

  2. CYP2D6

  3. CYP3A4

  4. CYP2C19

The correct answer is: CYP1A2

Smoking induces the enzyme CYP1A2, which can lead to increased metabolism of medications like warfarin and clopidogrel. This increased metabolism can result in lower drug levels in the body, reducing their effectiveness and potentially increasing the risk of bleeding. Therefore, smoking can have a significant impact on the pharmacokinetics of these medications. Options B, C, and D (CYP2D6, CYP3A4, CYP2C19) are not directly related to the metabolism of warfarin and clopidogrel in the context described in the question.

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