NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What helps to delay absorption and extend the duration of action in Insulin NPH?

Protamine
Lispro
Aspart
Glulisine

The correct answer is: Protamine

Protamine helps to delay absorption and extend the duration of action in Insulin NPH. Insulin NPH (Neutral Protamine Hagedorn) is a type of intermediate-acting insulin that has protamine added to it. This addition of protamine forms a crystalline complex with the insulin, which slows down its absorption after injection. This delay in absorption helps to provide a longer duration of action compared to regular insulin. The other options, Lispro, Aspart, and Glulisine, are all rapid-acting insulin analogs that do not contain protamine. These rapid-acting insulins have a quicker onset of action and a shorter duration of action compared to NPH insulin, making them inappropriate choices for delaying absorption and extending the duration of action like protamine does in Insulin NPH.