NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a primary management practice for diarrhea toxicity due to Irinotecan?

Give dexrazoxane
Atropine for early onset diarrhea
Administer Mesna
Use antifungals

The correct answer is: Atropine for early onset diarrhea

For diarrhea toxicity due to Irinotecan, the primary management practice is to administer Atropine for early onset diarrhea. Atropine is used to treat severe or early-onset diarrhea associated with Irinotecan by reducing gastrointestinal secretions and motility. This helps alleviate the symptoms of diarrhea and can improve the patient's overall comfort and quality of life during cancer treatment. Mesna (option C) is used to prevent ifosfamide-induced hemorrhagic cystitis. Dexrazoxane (option A) is a cardioprotective agent used to reduce the risk of cardiomyopathy associated with doxorubicin. Antifungals (option D) are used to manage fungal infections and are not indicated for diarrhea toxicity due to Irinotecan.