NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a significant risk when discontinuing HBV NRTIs?

  1. Exacerbations of HBV

  2. Decreased immunity

  3. Increased risk of infection

  4. Lactic acidosis

The correct answer is: Exacerbations of HBV

Discontinuing HBV (Hepatitis B Virus) NRTIs (Nucleoside Reverse Transcriptase Inhibitors) can lead to exacerbations of HBV. This is because abrupt cessation of HBV NRTIs can cause a flare-up of the hepatitis B infection, leading to worsening symptoms and potential liver damage. It is crucial to taper off these medications under the guidance of a healthcare provider to minimize the risk of HBV exacerbations. Options B, C, and D are incorrect as they do not directly relate to the specific risk associated with discontinuing HBV NRTIs. Decreased immunity, increased risk of infection, and lactic acidosis are potential adverse effects that may result from other medications or conditions, but they are not the primary concern when stopping HBV NRTIs.