NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is required for the administration of atazanavir (Reyataz)?

  1. Empty stomach

  2. Acidic gut environment for absorption

  3. Co-administration with ritonavir only

  4. No food restrictions

The correct answer is: Acidic gut environment for absorption

Atazanavir (Reyataz) is a protease inhibitor used in the treatment of HIV. The correct answer is B because an acidic gut environment is required for its optimal absorption. Atazanavir should be taken with food to lower the risk of gastrointestinal side effects such as nausea. Therefore, it is important to administer atazanavir with food to enhance its absorption and reduce the likelihood of side effects. Option A is incorrect because atazanavir should be taken with food, not on an empty stomach. Option C is incorrect because atazanavir can be co-administered with either ritonavir or cobicistat. Option D is incorrect because food intake is actually recommended when taking atazanavir.

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