NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is the black box warning for Tamoxifen?

  1. Increased risk of uterine or endometrial cancer

  2. Severe liver damage

  3. Risk of major depressive disorder

  4. Significant increase in blood pressure

The correct answer is: Increased risk of uterine or endometrial cancer

Tamoxifen, a medication commonly used in the treatment of breast cancer, carries a black box warning for an increased risk of uterine or endometrial cancer. This warning is due to the fact that Tamoxifen can act like estrogen in the uterus, which can lead to abnormal cell growth and an increased risk for cancer. Option B is incorrect because while there is a potential for liver damage, it is not listed as a black box warning. Option C is incorrect because Tamoxifen is not known to increase the risk of major depressive disorder. Option D is incorrect because Tamoxifen does not significantly increase blood pressure.

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