NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

What is the correct initial dosage for Colchicine (Colcrys) during an acute gout attack?

1. 2.0 mg PO

2. 1.6 mg PO in 2 hrs

3. 1.2 mg PO followed by 0.6 mg in 1 hr

4. 0.5 mg PO every hour for 4 hours

The correct answer is: 1.2 mg PO followed by 0.6 mg in 1 hr

During an acute gout attack, the correct initial dosage for Colchicine (Colcrys) is typically 1.2 mg orally followed by 0.6 mg one hour later. This dosing regimen helps alleviate inflammation and pain associated with gout while minimizing the risk of gastrointestinal side effects that can occur with higher doses. Option A is too high of a starting dose, which may increase the likelihood of side effects. Option B provides a high dose all at once, which can also lead to increased side effects. Option D suggests a dosing regimen that is too frequent, potentially resulting in excess drug accumulation and toxicity. Consequently, option C is the most appropriate choice for the initial dosage of Colchicine during an acute gout attack.