NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

What management strategy is recommended for Pulmonary fibrosis induced by bleomycin?

1. Administer Mesna

2. Limit dose of 2mg/dose

3. Steroids and stop therapy

4. Monitor for dry mouth

The correct answer is: Steroids and stop therapy

For pulmonary fibrosis induced by bleomycin, the recommended management strategy involves administering steroids and stopping the therapy. Steroids have anti-inflammatory properties that can help reduce the inflammation and damage caused by pulmonary fibrosis. By stopping the therapy, further exposure to bleomycin can be prevented, potentially halting or slowing down the progression of the fibrosis. The other options are not the recommended management strategy for pulmonary fibrosis induced by bleomycin: - Administering Mesna is used to prevent hemorrhagic cystitis caused by ifosfamide and cyclophosphamide, not for treating bleomycin-induced pulmonary fibrosis. - Limiting the dose of 2mg/dose does not address the underlying cause of the pulmonary fibrosis and may not be sufficient for adequate management. - Monitoring for dry mouth is important, but it is not the primary management strategy for bleomycin-induced pulmonary fibrosis; addressing the inflammation with steroids and discontinuing the therapy are the main considerations.