NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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What should tetracyclines be separated from during administration?

Food
Antacids and polyvalent cations
Probiotics
All liquids

The correct answer is: Antacids and polyvalent cations

Tetracyclines should be separated from antacids and polyvalent cations during administration. This is because these substances can bind to tetracyclines in the gastrointestinal tract, forming complexes that are poorly absorbed. Consequently, the effectiveness of the tetracycline can be significantly reduced if taken together with antacids or polyvalent cations. Therefore, it is recommended to separate the administration of tetracyclines from these substances to ensure optimal absorption and therapeutic effect of the antibiotic. Option A (Food) is not the correct answer because tetracyclines can generally be taken with food, unless stated otherwise in specific cases. Option C (Probiotics) are not typically contraindicated to be taken with tetracyclines. Option D (All liquids) is not specifically relevant in the context of separating tetracyclines from substances that could reduce its absorption like antacids and polyvalent cations.