NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What strategy is recommended to reduce Niacin's flushing effect?

  1. Take with food

  2. Administer once monthly

  3. Combine with PCSK9 inhibitors

  4. Take ASA 30-60 mins before dose

The correct answer is: Take ASA 30-60 mins before dose

To reduce Niacin's flushing effect, taking aspirin (ASA) 30-60 minutes before the Niacin dose is recommended. Flushing is a common side effect of Niacin therapy, characterized by redness, warmth, and itching of the skin. Aspirin helps to mitigate this effect by inhibiting prostaglandin synthesis, which is one of the main mediators of flushing. Taking Niacin with food or once monthly administration are not strategies specifically targeted at reducing flushing. Combining Niacin with PCSK9 inhibitors is unrelated to reducing the flushing effect of Niacin.

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