NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which antidepressants have the lowest risk for sexual dysfunction?

  1. Sertraline and Trazodone

  2. Nefazodone and Duloxetine

  3. Bupropion and Mirtazapine

  4. Venlafaxine and Desvenlafaxine

The correct answer is: Bupropion and Mirtazapine

Antidepressants such as bupropion and mirtazapine are known to have the lowest risk for causing sexual dysfunction among the options provided. Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) and mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). These two classes of antidepressants are less likely to cause sexual side effects compared to other classes such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). Sertraline and trazodone (Option A) are associated with a moderate risk of sexual dysfunction. Nefazodone and duloxetine (Option B) have a higher risk of inducing sexual dysfunction compared to bupropion and mirtazapine. Venlafaxine and desvenlafaxine (Option D) belong to the SNRI class and are more likely to cause sexual side effects than bupropion and mirtazapine.

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