NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which characteristic is NOT associated with hydrophilic antibiotics?

  1. Poor to moderate bioavailability

  2. Active against intracellular pathogens

  3. Renal elimination

  4. Increased clearance in sepsis

The correct answer is: Active against intracellular pathogens

Hydrophilic antibiotics are known for having poor to moderate bioavailability, being eliminated mainly through renal excretion, and experiencing increased clearance in conditions such as sepsis. However, they are typically not effective against intracellular pathogens because their hydrophilic nature makes it difficult for them to penetrate cell membranes. Therefore, the characteristic NOT associated with hydrophilic antibiotics is being active against intracellular pathogens.

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