NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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Which drug should not be used alone to avoid resistance?

Flucytosine
Azole antifungals
Echinocandins
Griseofulvin

The correct answer is: Flucytosine

Flucytosine should not be used alone to avoid resistance. This is because resistance to flucytosine can develop rapidly if it is used as monotherapy. Therefore, it is recommended to use flucytosine in combination with other antifungal agents to prevent the emergence of drug resistance. Azole antifungals, echinocandins, and griseofulvin are not typically associated with rapid development of resistance when used alone. Azoles work by inhibiting the synthesis of ergosterol in the fungal cell membrane, echinocandins target the fungal cell wall, and griseofulvin disrupts the microtubule function of fungal cells. These mechanisms of action make it less likely for resistance to develop quickly when these drugs are used as monotherapy.