NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication inhibits CYP-2C9?

  1. Methadone

  2. Hydrocodone

  3. Amiodarone

  4. Efavirenz

The correct answer is: Amiodarone

Amiodarone is a medication typically used to treat heart rhythm problems, also known as arrhythmias. It works by inhibiting the enzyme CYP-2C9, which is responsible for breaking down certain medications in the body. This allows those medications to stay in the body longer and can increase their effects. Methadone and hydrocodone are both opioids, which function differently from amiodarone and therefore do not inhibit CYP-2C9. Efavirenz, an antiretroviral medication used to treat HIV, primarily inhibits different enzymes in the body and does not specifically target CYP-2C9. It is important to note that inhibiting CYP-2C9 can also lead to potential drug interactions and requires close monitoring by a healthcare provider.

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