NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is contraindicated in neonates (1-28 days)?

  1. Promethazine

  2. Codeine

  3. Tramadol

  4. CTX

The correct answer is: CTX

CTX, or Chloramphenicol, is contraindicated in neonates (1-28 days) due to the risk of gray baby syndrome, a potentially fatal adverse effect. Chloramphenicol can inhibit mitochondrial protein synthesis in newborns, leading to toxicity and potentially fatal consequences. Therefore, it is essential to avoid using Chloramphenicol in neonates to prevent this severe adverse reaction. Promethazine, codeine, and tramadol are not contraindicated in neonates; however, caution should be exercised when prescribing these medications to infants due to potential adverse effects.

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