NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which vasodilator can cause cyanide toxicity particularly in patients with renal or hepatic insufficiency?

  1. Nitroglycerin

  2. Nitroprusside

  3. Isosorbide dinitrate

  4. Hydralazine

The correct answer is: Nitroprusside

Nitroprusside is the correct answer because it contains a cyanide moiety that can lead to cyanide toxicity, especially in patients with renal or hepatic insufficiency. Nitroglycerin, isosorbide dinitrate, and hydralazine do not contain cyanide and therefore do not pose the same risk of cyanide toxicity as nitroprusside.

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