NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Thiazide diuretics work by inhibiting sodium reabsorption in the distal convoluted tubule (DCT) of the nephron. By doing so, they increase the excretion of sodium and water, leading to diuresis and a reduction in blood volume. This mechanism of action helps in lowering blood pressure and treating conditions such as hypertension and edema. It is important to note that the other options are not correct because Thiazide diuretics specifically target sodium reabsorption in the DCT, rather than affecting aldosterone, renin, or calcium channels.