NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

When Tygecycline is used in patients taking warfarin, it can lead to an increase in the International Normalized Ratio (INR). Tygecycline can inhibit the metabolism of warfarin, leading to higher levels of warfarin in the blood and subsequently increasing the INR. This interaction can potentially result in an increased risk of bleeding for the patient. Therefore, monitoring the INR closely and adjusting warfarin doses accordingly is crucial in these situations.

Option A is incorrect because the expected effect when using Tygecycline in patients taking warfarin is an increase in the INR, not a decrease.

Option C is incorrect as there is an established interaction between Tygecycline and warfarin that can impact the INR.

Option D is incorrect as the side effect associated with Tygecycline in patients taking warfarin is primarily related to the INR levels and not a decrease in blood pressure.