NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Tygecycline is the correct answer because it has a black box warning for an increased risk of death. Tigecycline is a glycylcycline antibiotic used to treat complicated skin and skin structure infections, intra-abdominal infections, and community-acquired bacterial pneumonia. The black box warning for tigecycline includes an increased risk of death compared to other antibiotics, especially when used to treat serious infections. This warning is important for healthcare providers to consider when choosing the appropriate antibiotic therapy for their patients.

Metronidazole (Choice A), Rifaximin (Choice C), and Clindamycin (Choice D) do not have black box warnings for an increased risk of death. Metronidazole is commonly used to treat anaerobic infections and parasitic infections. Rifaximin is used for the treatment of travelers' diarrhea and hepatic encephalopathy. Clindamycin is a lincosamide antibiotic used to treat various bacterial infections.