NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Acute treatment of a depressive episode in bipolar disorder may include all of the following except:

Aripiprazole
Valproate
Lamotrigine
Sertraline

The correct answer is: Sertraline

Acute treatment of a depressive episode typically involves medication to help manage symptoms and stabilize mood. In bipolar disorder, drugs used for treating depression may cause a switch to a manic episode, which is why it is important to use caution when prescribing medication for depression in bipolar disorder. Aripiprazole, Valproate, and Lamotrigine have been shown to be effective in treating depressive symptoms in bipolar disorder without causing a switch to mania. Sertraline, on the other hand, has the potential to induce mania and is generally not recommended for acute treatment of a depressive episode in bipolar disorder. Therefore, it would not be included in the treatment plan.