NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Chemotherapy drugs like Cyclophosphamide and Ifosfamide are best supplemented with what to mitigate a specific side effect?

Mesna and hydration
Antiemetics
Corticosteroids
Blood transfusions

The correct answer is: Mesna and hydration

Mesna and hydration are recommended for chemotherapy drugs like Cyclophosphamide and Ifosfamide in order to mitigate the specific side effect of hemorrhagic cystitis. This combination helps to protect the bladder lining from the harsh effects of these chemotherapy drugs. Antiemetics are used to prevent nausea and vomiting, corticosteroids are used to reduce inflammation and allergic reactions, and blood transfusions are used to replace blood cells in case of anemia. While these options may also be important for overall treatment, they do not specifically address the side effect of hemorrhagic cystitis. Therefore, they are not the best supplements for these chemotherapy drugs.