NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Choose a CYP-1A2 inhibitor from the list below.

Fluvoxamine
Sirolimus
Aprepitant
Hydrocodone

The correct answer is: Fluvoxamine

A CYP-1A2 inhibitor is a substance that blocks the activity of the enzyme CYP-1A2, which is responsible for breaking down various medications and toxins in the body. This inhibition can lead to potential drug interactions and side effects. Fluvoxamine is the only option here that is a known CYP-1A2 inhibitor. Sirolimus, Aprepitant, and Hydrocodone are not known to inhibit CYP-1A2. Sirolimus is an mTOR inhibitor, Aprepitant is a substance P antagonist, and Hydrocodone is an opioid analgesic. While these medications may have other interactions and side effects, they do not specifically inhibit CYP-1A2.