NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Fentanyl must not be used in opioid-naive patients unless they have been taking at least what equivalent of morphine per day for 7 days?

  1. 30mg

  2. 60mg

  3. 90mg

  4. 120mg

The correct answer is: 60mg

Fentanyl is a potent opioid medication and should only be used in opioid-tolerant patients. The equivalent dose of morphine required for opioid tolerance varies among individuals, but the general recommendation is at least 60mg of morphine per day for 7 days. This is because a higher dose of morphine over a longer period of time can help develop tolerance and reduce the risk of severe side effects from fentanyl in opioid-naive patients. Answer options A, C, and D are incorrect because they suggest different doses of morphine, which may not provide enough opioid tolerance for fentanyl use.

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