NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For delayed CINV, which medication is recommended?

Benzos
NK1-RA
5HT-3 RAs
Corticosteroids

The correct answer is: NK1-RA

For delayed chemotherapy-induced nausea and vomiting (CINV), Neurokinin-1 receptor antagonists (NK1-RAs) are recommended. NK1-RAs such as aprepitant have been shown to be effective in preventing and managing delayed CINV by blocking the action of substance P in the central nervous system. This helps in reducing nausea and vomiting in patients undergoing chemotherapy. Option A (Benzos) are not typically recommended as the first-line treatment for delayed CINV. Option C (5HT-3 RAs) are more commonly used for acute CINV rather than delayed CINV. Option D (Corticosteroids) might be used in combination with other antiemetic agents, including NK1-RAs, for the management of CINV, but they are not specifically recommended as the first-line treatment for delayed CINV.