NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For diabetic foot infections requiring MRSA/pseudomonas coverage, which of the following is an acceptable combination?

Vancomycin + Metronidazole
Ceftazidime + Carbapenem
Vancomycin + Ceftazidime
Vanco + Aztreonam

The correct answer is: Vancomycin + Ceftazidime

For diabetic foot infections requiring MRSA and Pseudomonas coverage, an acceptable combination includes Vancomycin and Ceftazidime. Vancomycin covers MRSA, which is a common pathogen in such infections, while Ceftazidime is effective against Pseudomonas aeruginosa, another common pathogen in diabetic foot infections. This combination provides broad coverage against both pathogens commonly seen in diabetic foot infections compared to the other options. Option A (Vancomycin + Metronidazole) does not cover Pseudomonas aeruginosa. Option B (Ceftazidime + Carbapenem) is not an ideal combination for both MRSA and Pseudomonas coverage. Option D (Vancomycin + Aztreonam) does not cover Pseudomonas aeruginosa adequately for a diabetic foot infection where dual coverage is needed.