NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For ICU delirium, which medication may decrease the duration?

  1. Midazolam

  2. Propofol

  3. Dexmedetomidine

  4. Quetiapine

The correct answer is: Quetiapine

Quetiapine may decrease the duration of ICU delirium because it is an antipsychotic medication that has been shown to effectively treat delirium in critically ill patients. It works by targeting the dopamine and serotonin receptors in the brain, which are believed to play a role in the development of delirium. On the other hand, midazolam and propofol are sedatives commonly used in the ICU, but they can actually contribute to the development of delirium if used for prolonged periods. Dexmedetomidine, a sedative commonly used in the ICU, has been shown to reduce the incidence or severity of delirium, but it has not been shown to decrease the duration. Therefore, quetiapine is the most appropriate choice for reducing the duration of ICU delirium.