NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For infective endocarditis, which combination of antibiotics is indicated for empiric treatment?

  1. Vanco + Ceftriaxone

  2. Vanco + CTX

  3. Penicillin + Gentamicin

  4. CTX + Rifampin

The correct answer is: Vanco + CTX

Empiric treatment refers to a treatment, in this case medication, that may be used before the true cause is identified. In order to start treatment as soon as possible, a broad spectrum of antibiotics is often used. Options A and B are incorrect because they only cover one type of bacteria, while option C only covers two types. Option D is incorrect because it does not include Vancomycin, which is necessary for treating MRSA (methicillin-resistant Staphylococcus aureus). Therefore, the best combination of antibiotics for empiric treatment of infective endocarditis is Vancomycin and CTX.