NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For management of severe asthma with an eosinophilic phenotype, which class of medication is used?

  1. Beta-2 adrenergic agonists

  2. Corticosteroids

  3. Interleukin receptor antagonists

  4. Phosphodiesterase inhibitors

The correct answer is: Interleukin receptor antagonists

Interleukin receptor antagonists are the most effective class of medications for managing severe asthma with an eosinophilic phenotype. These medications specifically target the inflammatory response and the high levels of eosinophils in the airways, making them the most appropriate choice for this condition. Beta-2 adrenergic agonists may provide symptom relief, but they do not target the underlying cause of the asthma. Corticosteroids are effective for managing inflammation, but may not be enough for severe asthma with an eosinophilic phenotype. Phosphodiesterase inhibitors are used for treating other respiratory conditions, such as chronic obstructive pulmonary disease, and are not the first-line choice for asthma management.

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