NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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For perioperative antibiotic selection in orthopedic surgery, what is recommended for patients with beta-lactam allergy?

Cefazolin
Metronidazole
Clindamycin or vancomycin
Cefoxitin

The correct answer is: Clindamycin or vancomycin

When it comes to perioperative antibiotic selection for orthopedic surgery, patients with a beta-lactam allergy should be given clindamycin or vancomycin. This is because these antibiotics are effective against common orthopedic pathogens and do not contain any beta-lactam components, making them a safe choice for patients with an allergy. Option A (cefazolin) is incorrect because it is a beta-lactam antibiotic. Option B (metronidazole) is also incorrect because it is not typically used for perioperative prophylaxis in orthopedic surgery. Option D (cefoxitin) is not recommended for patients with beta-lactam allergies as it can cause cross-reactivity. Therefore, option C is the best choice for patients with a beta-lactam allergy.