NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For which class of HIV medications is gene testing recommended before use?

  1. NRTIs

  2. NNRTIs

  3. PIs

  4. INSTIs

The correct answer is: NRTIs

Gene testing before initiating treatment with NRTIs (nucleoside reverse transcriptase inhibitors) is recommended to evaluate for the presence of specific genetic mutations, such as HLA-B*5701. This mutation is associated with a higher risk of developing a hypersensitivity reaction to abacavir, an NRTI. Therefore, prior to starting NRTI therapy, gene testing helps identify patients who may be at risk for this serious adverse drug reaction. The other classes of HIV medications listed (NNRTIs, PIs, and INSTIs) do not typically require gene testing before initiation.

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