NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For which compound is Amifostine used as a chemoprotectant?

  1. Doxorubicin

  2. Cisplatin

  3. Etoposide

  4. Mitoxantrone

The correct answer is: Cisplatin

Amifostine is used as a chemoprotectant in combination with cisplatin. Amifostine functions by reducing the nephrotoxicity of cisplatin, as well as decreasing the incidence of neurotoxicity, particularly peripheral neuropathy associated with cisplatin chemotherapy. Therefore, the correct answer is B. Doxorubicin, Etoposide, and Mitoxantrone are not typically paired with Amifostine as a chemoprotectant.

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