NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For which condition is an increase in AST over ALT, with AST about double, a characteristic?

  1. Chronic liver disease

  2. Hepatic encephalopathy

  3. Jaundice

  4. Alcoholic liver disease

The correct answer is: Alcoholic liver disease

An increase in AST over ALT, with AST about double, is a characteristic seen in alcoholic liver disease. This is due to the damage and inflammation caused by excessive alcohol consumption on the liver, which can lead to elevated levels of AST in the bloodstream. The other conditions listed, such as chronic liver disease, hepatic encephalopathy, and jaundice, may also be associated with elevated liver enzymes, but they do not exhibit the specific pattern of AST being about double the amount of ALT. Therefore, these options are incorrect and do not satisfy the criteria given in the question for the characteristic being described.

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