NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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For which drug is correcting hypokalemia and hypomagnesemia prior to use important?

  1. Dronedarone

  2. Ibutilide

  3. Flecainide

  4. Sotalol

The correct answer is: Ibutilide

Correcting hypokalemia and hypomagnesemia prior to using drugs that prolong the QT interval is crucial to reduce the risk of serious cardiac arrhythmias such as Torsades de Pointes. Ibutilide is known to prolong the QT interval, which can increase the risk of Torsades de Pointes. Therefore, it is important to correct any electrolyte abnormalities, specifically hypokalemia and hypomagnesemia, before administering Ibutilide to minimize the risk of adverse cardiac events. On the other hand, Dronedarone, Flecainide, and Sotalol are also antiarrhythmic drugs, but they are not typically associated with the same level of QT prolongation as Ibutilide.

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