NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Identify a substrate of CYP-1A2.

  1. S-warfarin

  2. Theophylline

  3. Methadone

  4. Tacrolimus

The correct answer is: Theophylline

CYP-1A2 is an enzyme in the liver that is responsible for metabolizing substances in our body. The other options, S-warfarin, methadone, and tacrolimus, are also substrates that are metabolized by other enzymes. S-warfarin, for example, is primarily metabolized by CYP-2C9, while methadone is metabolized by CYP-3A4 and CYP-2D6. Tacrolimus is metabolized by multiple enzymes, including CYP-3A4. Therefore, only theophylline is correctly identified as a substrate of CYP-1A2.

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