NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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In inpatient settings, which antibiotics are indicated for severe purulent SSTIs?

  1. Cephalexin

  2. SMX/TMP, Doxycycline

  3. Vancomycin, Daptomycin, Linezolid

  4. Amoxicillin

The correct answer is: Vancomycin, Daptomycin, Linezolid

Severe purulent SSTIs are typically caused by resistant bacteria, making broad-spectrum antibiotics necessary. Cephalexin (A) and Amoxicillin (D) are not considered broad-spectrum and would not effectively treat these infections. While SMX/TMP and Doxycycline (B) are broad-spectrum, they are not as effective against severe purulent SSTIs compared to the antibiotics listed in option C. Vancomycin, Daptomycin, and Linezolid (C) have excellent coverage against gram-positive bacteria, including the resistant strains commonly found in severe purulent SSTIs. Therefore, they are the preferred antibiotics for this type of infection in an inpatient setting.

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