NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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In the management of HIT, what is the threshold for platelets recovery before starting warfarin therapy?

  1. 100,000/mm3

  2. 150,000/mm3

  3. 200,000/mm3

  4. 250,000/mm3

The correct answer is: 150,000/mm3

Platelets are important for blood clotting and a low platelet count increases the risk of bleeding, while a high platelet count can increase the risk of blood clots. In patients with heparin-induced thrombocytopenia (HIT) who need warfarin therapy, it is important to have an adequate platelet count before starting the medication. A platelet count of 150,000 per cubic millimeter (mm3) is considered the threshold for adequate platelet recovery and is the safest level to start warfarin therapy. The other options, 100,000/mm3, 200,000/mm3, and 250,000/mm3, are either too low or too high and may increase the risk of bleeding or blood clots. Therefore, the correct answer is B 150,000/mm3.

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