NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ketoconazole is particularly noted for its risk of:

  1. Nephrotoxicity

  2. Hepatotoxicity

  3. Myelosuppression

  4. QT prolongation

The correct answer is: Hepatotoxicity

Ketoconazole is particularly noted for its risk of hepatotoxicity. This adverse effect is well-documented and pharmacists should monitor patients taking ketoconazole for signs of liver damage. It is important to be cautious and consider alternative treatments in patients who are at a higher risk of developing liver issues. Nephrotoxicity, myelosuppression, and QT prolongation are not typically associated with ketoconazole use. While these side effects can occur with other medications, they are not the primary concern when using ketoconazole.