NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Quinolones have a broad spectrum of activity against:

  1. Gram-negative bacteria only

  2. Atypicals only

  3. Gram-negative, Gram-positive, and atypicals

  4. Anaerobes

The correct answer is: Gram-negative, Gram-positive, and atypicals

Quinolones have a broad spectrum of activity against a variety of pathogens, including both Gram-negative and Gram-positive bacteria, as well as atypical bacteria. This makes option C the correct answer. Gram-negative bacteria only (option A) and atypicals only (option B) are incorrect because quinolones act on a wider range of pathogens beyond these categories. Anaerobes (option D) are generally not well covered by quinolones, as they are more effective against aerobic organisms.

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