NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

What adverse effect is common with EGFR inhibitors like Cetuximab?

1. Weight gain

2. Acneiform rash

3. Hypothyroidism

4. Muscle pain

The correct answer is: Acneiform rash

EGFR inhibitors, such as Cetuximab, are used to treat certain types of cancer by inhibiting the EGFR protein, which plays a role in cell growth and division. This type of medication is known to commonly cause an acneiform rash, which is a rash that resembles acne. This occurs because the medication can also inhibit the growth of skin cells, leading to skin irritation and inflammation. Weight gain, hypothyroidism, and muscle pain are not commonly associated with EGFR inhibitors, making them incorrect options. Weight gain and hypothyroidism may be side effects of other cancer treatments, and muscle pain is not a known adverse effect of EGFR inhibitors.