NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What are the first-line treatments for MSSA?

  1. Dicroxacillin, oxacillin

  2. Vancomycin, Linezolid

  3. SMX/TMP, Doxycycline

  4. Cefazolin, cephalexin

The correct answer is: Cefazolin, cephalexin

The first-line treatments for MSSA (Methicillin-sensitive Staphylococcus aureus) infections are beta-lactam antibiotics such as cefazolin and cephalexin. These antibiotics are effective against MSSA due to their ability to inhibit the synthesis of the bacterial cell wall, leading to bacterial cell death. Other options listed are not the first-line treatments for MSSA. Vancomycin and Linezolid are usually reserved for MRSA (Methicillin-resistant Staphylococcus aureus) infections. Dicloxacillin and oxacillin are also effective against MSSA but are not preferred as first-line treatments. SMX/TMP (Sulfamethoxazole/Trimethoprim) and Doxycycline are more commonly used for other types of bacterial infections, not specifically for MSSA.

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