NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What can cause malignant hyperthermia?

  1. Lidocaine

  2. Desflurane

  3. Bupivacaine

  4. Ropivacaine

The correct answer is: Desflurane

Malignant hyperthermia is a rare but potentially life-threatening condition that can be triggered by certain drugs used during anesthesia, such as volatile anesthetics like desflurane. In susceptible individuals, exposure to triggering agents like desflurane can lead to uncontrolled release of calcium from the sarcoplasmic reticulum in skeletal muscle cells, resulting in a hypermetabolic state characterized by severe muscle contractions, hyperthermia, acidosis, and potential organ damage. Lidocaine, bupivacaine, and ropivacaine are local anesthetics and are not typically associated with causing malignant hyperthermia.

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