NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What combination is used for high emetic risk chemotherapy regimens?

  1. NK1-RA + 5HT3-RA + Corticosteroids

  2. NK1-RA + 5HT3-RA + Olanzapine + Dexamethasone

  3. 5HT3-RA + Dexamethasone

  4. Palonosetron + Olanzapine + Dexamethasone

The correct answer is: NK1-RA + 5HT3-RA + Olanzapine + Dexamethasone

High emetic risk chemotherapy regimens require a combination of four different drugs a NK1-RA (neurokinin-1 receptor antagonist), a 5HT3-RA (serotonin 5-HT3 receptor antagonist), olanzapine, and dexamethasone. Option A only contains three of the required drugs, missing olanzapine. Option C only contains two of the required drugs, missing both NK1-RA and olanzapine. Option D contains the four required drugs, but uses palonosetron instead of 5HT3-RA, which is not the recommended combination for high emetic risk chemotherapy regimens. Option B includes all four required drugs in the recommended combination.

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