NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What common warning is shared by all listed JAK inhibitors?

Gastrointestinal upset
Thrombosis
Nausea
Muscle pain

The correct answer is: Thrombosis

All of the options listed as choices can be potential side effects of JAK inhibitors; however, only thrombosis, or blood clotting, is considered to be a common warning that is shared by all listed JAK inhibitors. This is because JAK inhibitors work by suppressing certain enzymes responsible for inflammation, but these same enzymes are also responsible for blood clotting. Therefore, taking JAK inhibitors can increase the risk of developing blood clots, which can lead to serious complications. Gastrointestinal upset, nausea, and muscle pain are all possible side effects that may occur, but they are not considered to be common warnings shared by all JAK inhibitors. These side effects may only occur in certain individuals or with specific JAK inhibitors, whereas thrombosis is a known and common risk shared by all listed JAK inhibitors.