NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

What does a preferred initial ART regimen in most treatment-naive adults include?

1. 1 NNRTI and 2 NRTIs

2. 2 NRTIs and 1 INSTI

3. 3 PIs

4. 2 INSTIs and 1 NNRTI

The correct answer is: 2 NRTIs and 1 INSTI

A Option A is incorrect because a preferred initial ART regimen typically includes 2 NRTIs and 1 INSTI, not 1 NNRTI and 2 NRTIs. B: This is the correct answer because a preferred initial ART regimen for most treatment-naive adults typically includes 2 NRTIs and 1 INSTI. NRTIs and INSTIs are two types of antiretroviral drugs that prevent the HIV virus from replicating. This combination is considered effective and safe for most people starting HIV treatment. C: Option C is incorrect because 3 PIs (protease inhibitors) are typically not used as a preferred initial ART regimen for most treatment-naive adults. PIs are generally reserved for more complicated cases or when other regimens are not effective. D: Option D is incorrect because a preferred initial ART regimen typically does not include 2 INSTIs and 1 NNRTI. As mentioned before, a combination of 2 NRTIs and 1 INSTI is typically considered the most effective and safe for most treatment-naive adults.