NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What does bioavailability measure?

  1. 100 x (AUC intravenous/AUC extravascular)

  2. 100 x (AUC extravascular/AUC intravenous) x (Dose intravenous/ Dose extravascular)

  3. 100 x (Dose extravascular/AUC intravenous)

  4. (AUC extravascular/AUC intravenous) x 100

The correct answer is: 100 x (AUC extravascular/AUC intravenous) x (Dose intravenous/ Dose extravascular)

Bioavailability measures the fraction of a drug that reaches systemic circulation after administration via non-intravenous routes (e.g. oral, subcutaneous, intramuscular, etc.). This involves comparing the systemic exposure of the drug after extravascular administration to the systemic exposure after intravenous administration, taking into account the dose used for each route. Therefore, options A, C, and D are incorrect because they do not include the dose factor. Option B is the correct calculation for bioavailability.

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