NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What does esomeprazole act as in relation to CYP-2C19?

Substrate
Inhibitor
Inducer
None of the above

The correct answer is: Inhibitor

Esomeprazole is a medication primarily used to help with acid reflux and stomach ulcers. In relation to CYP-2C19, it acts as an inhibitor. This means that it can block or lower the activity of this specific enzyme, which could affect the breakdown and clearance of other medications metabolized by this enzyme. Options A, C, and D are incorrect because esomeprazole is not a substrate, inducer, or unrelated to CYP-2C19. It is important to note that medication interactions can occur when combining esomeprazole with other medications metabolized by CYP-2C19, so it is important to consult with a healthcare provider before taking multiple medications.