NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What drug is used to prevent cerebral artery vasospasm after an acute subarachnoid hemorrhage?

Nimodipine
Mannitol
Clopidogrel
Aspirin

The correct answer is: Nimodipine

Nimodipine is the correct answer because it is a dihydropyridine calcium channel blocker that specifically acts on cerebral blood vessels. It is the only medication among the choices listed that has been shown to prevent cerebral artery vasospasm after an acute subarachnoid hemorrhage. Nimodipine helps to improve blood flow in the brain by selectively dilating cerebral arteries without significantly affecting systemic blood pressure. This targeted action makes it an important pharmacological agent in the prevention of vasospasm-related complications following subarachnoid hemorrhage. On the other hand, Mannitol is an osmotic diuretic used to reduce intracranial pressure and cerebral edema but does not prevent cerebral artery vasospasm. Clopidogrel and Aspirin are antiplatelet agents primarily used to prevent thrombotic events and are not indicated for preventing cerebral artery vasospasm after subarachnoid hemorrhage.