NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What effect do Glycoprotein IIb/IIIa Receptor Antagonists have on platelet function?

  1. Increase platelet production

  2. Permanently bind to platelets

  3. Temporarily inhibit platelet aggregation

  4. Reduce clotting factors

The correct answer is: Temporarily inhibit platelet aggregation

Glycoprotein IIb/IIIa receptor antagonists, such as abciximab, eptifibatide, and tirofiban, work by temporarily inhibiting platelet aggregation. These medications block the glycoprotein IIb/IIIa receptor on the platelet surface, preventing the binding of fibrinogen and thereby inhibiting platelet aggregation and reducing clot formation. This leads to decreased platelet function and helps prevent unwanted clot formation in conditions such as acute coronary syndromes and during percutaneous coronary interventions.

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