NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a black box warning for Lomitapide?

  1. Constipation

  2. Hepatotoxicity

  3. Myopathy

  4. Increased blood pressure

The correct answer is: Hepatotoxicity

Lomitapide carries a black box warning for hepatotoxicity. This warning is included because the drug has the potential to cause liver damage, which can be severe and even life-threatening. Monitoring liver function tests regularly is crucial when prescribing lomitapide to reduce the risk of hepatotoxicity. Constipation, myopathy, and increased blood pressure are not the primary concerns associated with lomitapide that warrant a black box warning.