NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a characteristic effect of Degarelix and Relugolix?

  1. Increased risk of osteoporosis and tumor flare

  2. Osteoporosis risk, no tumor flare

  3. Immediate increase in testosterone

  4. High risk of gynecomastia

The correct answer is: Osteoporosis risk, no tumor flare

Both Degarelix and Relugolix are gonadotropin-releasing hormone (GnRH) antagonists, which means they inhibit the production of sex hormones such as testosterone. This results in a decreased risk of osteoporosis, as seen in option B. Option A is incorrect because it includes an incorrect characteristic effect, tumor flare, which is actually a possible outcome when starting GnRH agonist treatment, not antagonist treatment. Option C is incorrect because it suggests an immediate increase in testosterone, which is not a characteristic effect of these drugs. Option D is also incorrect because gynecomastia is not a known side effect of Degarelix and Relugolix. Overall, the correct answer, option B, is the only one that accurately describes the characteristic effect of these drugs.

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