NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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What is a common adverse effect of cannabinoids when used for CINV?

Hyponatremia
Somnolence
Seizures
Fluid retention

The correct answer is: Somnolence

When cannabinoids are used for chemotherapy-induced nausea and vomiting (CINV), a common adverse effect is somnolence, which refers to a strong desire for sleep or a need to nap. This side effect can impair a patient's ability to carry out daily activities or operate machinery safely. It is important for healthcare providers to educate patients about the potential for somnolence when using cannabinoids for CINV to help them take necessary precautions and prevent any related accidents or injuries. The other options are not common adverse effects associated with cannabinoids used for CINV. Hyponatremia is more commonly seen with certain medications like thiazide diuretics or syndrome of inappropriate antidiuretic hormone secretion (SIADH). Seizures are not a common adverse effect of cannabinoids for CINV, and they are more likely to be used to treat seizure disorders like epilepsy. Fluid retention is not a common adverse effect of cannabinoids used for CINV either.